全文获取类型
收费全文 | 17850篇 |
免费 | 1656篇 |
国内免费 | 1391篇 |
专业分类
耳鼻咽喉 | 210篇 |
儿科学 | 211篇 |
妇产科学 | 206篇 |
基础医学 | 2021篇 |
口腔科学 | 368篇 |
临床医学 | 2332篇 |
内科学 | 2637篇 |
皮肤病学 | 123篇 |
神经病学 | 933篇 |
特种医学 | 579篇 |
外国民族医学 | 16篇 |
外科学 | 1883篇 |
综合类 | 3314篇 |
现状与发展 | 5篇 |
一般理论 | 5篇 |
预防医学 | 1163篇 |
眼科学 | 428篇 |
药学 | 1928篇 |
4篇 | |
中国医学 | 906篇 |
肿瘤学 | 1625篇 |
出版年
2024年 | 7篇 |
2023年 | 255篇 |
2022年 | 429篇 |
2021年 | 742篇 |
2020年 | 692篇 |
2019年 | 601篇 |
2018年 | 654篇 |
2017年 | 613篇 |
2016年 | 581篇 |
2015年 | 853篇 |
2014年 | 1027篇 |
2013年 | 853篇 |
2012年 | 1277篇 |
2011年 | 1541篇 |
2010年 | 978篇 |
2009年 | 730篇 |
2008年 | 897篇 |
2007年 | 1015篇 |
2006年 | 956篇 |
2005年 | 947篇 |
2004年 | 668篇 |
2003年 | 611篇 |
2002年 | 553篇 |
2001年 | 481篇 |
2000年 | 425篇 |
1999年 | 432篇 |
1998年 | 302篇 |
1997年 | 317篇 |
1996年 | 222篇 |
1995年 | 236篇 |
1994年 | 170篇 |
1993年 | 131篇 |
1992年 | 130篇 |
1991年 | 104篇 |
1990年 | 86篇 |
1989年 | 80篇 |
1988年 | 84篇 |
1987年 | 58篇 |
1986年 | 50篇 |
1985年 | 34篇 |
1984年 | 20篇 |
1983年 | 12篇 |
1982年 | 10篇 |
1981年 | 9篇 |
1980年 | 10篇 |
1979年 | 9篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 109 毫秒
41.
42.
Child Psychiatry & Human Development - Preschoolers’ emotional development typically hinges on the family emotional climate and their interactions with caregivers. This study used a... 相似文献
43.
44.
Wei-Qiang He Huan-Li Wang Dao-Qing Zhong Lu-Yang Lin Xiao-Shan Qiu Ri-Dong Yang 《International journal of clinical and experimental pathology》2015,8(5):5775-5780
The ratio of patients with RPR constant positive more than 2 years despite receiving standard syphilis treatment has been reported to be 11.54%~31.3%. The current interpretations on this phenomenon are cellular immune function restrained and the existence of neurosyphilis or asymptomatic neurosyphilis. We conducted this study to detect the treponemal antibody in cerebrospinal fluid (CSF) and lymphocyte subsets in peripheral blood of syphilis patients with persisting RPR positive more than 2 years without neurologic signs, and then explore their relationship. In this study, Treponemal antibody in CSF of 46 syphilitic with HIV negative were measured by syphilis serum test and compared with that of 5 neurosyphilis. Lymphocyte subsets were measured by flow cytometry (FCM) and compared with that of 30 healthy controls. We observed that treponemal antibody in CSF was detected not only in 12 cases (25.21%) of 46 treated patients, but also in 5 neurosyphilis. The ratio of lymphocyte subsets revealed that CD3+, CD4+ T cells and natural killer (NK) cells showed no significant differences between the patient and healthy controls (P > 0.05), while CD8+ T cells in patients were significant higher than that in healthy controls (P < 0.001). Lymphocyte subsets showed no significant differences between the patients with treponemal antibody positive and negative in CSF (P > 0.05). In conclusion, the treponemal antibody in CSF of treated patients suggests that part of them were asymptomatic neurosyphilis and with cellular immunodifeciency. And there is no significant relationship between asymptomatic neurosyphilis and cellular immunodeficiency in peripheral blood. 相似文献
45.
Ila Datar Xiaoliang Qiu Hong Zhi Ma Miranda Yeung Shweta Aras Ivana de la Serna Fahd Al-Mulla Jean Paul Thiery Robert Trumbly Xuan Fan Hongjuan Cui Kam C. Yeung 《Oncotarget》2015,6(36):39050-39061
Accumulating evidence suggests that presence of macrophages in the tumor microenvironment add to the invasive and tumor-promoting hallmarks of cancer cells by secreting angiogenic and growth factors. RKIP is a known metastasis suppressor and interferes with several steps of metastasis. However, the mechanistic underpinnings of its function as a broad metastasis suppressor remain poorly understood. Here, we establish a novel pathway for RKIP regulation of metastasis inhibition through the negative regulation of RANTES/CCL5 thereby limiting tumor macrophage infiltration and inhibition of angiogenesis. Using a combination of loss- and gain-of-function approaches, we show that RKIP hinders breast cancer cell invasion by inhibiting expression of the CC chemokine CCL5 in vitro. We also show that the expression levels of RKIP and CCL5 are inversely correlated among clinical human breast cancer samples. Using a mouse allograft breast cancer transplantation model, we highlight that ectopic expression of RKIP significantly decreases tumor vasculature, macrophage infiltration and lung metastases. Mechanistically, we demonstrate that the inhibition of the CCL5 expression is the cause of the observed effects resulting from RKIP expression. Taken together, our results underscore the significance of RKIP as important negative regulator of tumor microenvironment. 相似文献
46.
47.
Chen Qiu Chunlong Zheng Linhai Zhu Xiao Qu Hongchang Shen Jiajun Du 《International journal of clinical and experimental pathology》2015,8(4):3785-3793
The aim of this study was to examine β-arrestin1 expression in patients with lung adenocarcinoma (ADC) and explore the relationship of β-arrestin1 protein with clinicopathologic factors, vascular endothelial growth factor (VEGF) and prognosis. A total of 105 surgically resected lung adenocarcinoma patients were recruited for the study. The expression of β-arrestin1 and VEGF were determined by immunohistochemistry (IHC). The score measuring the β-arrestin1 and VEGF were calculated by combining the percentage of positive cells and the intensity of staining. Kaplan-Meier method and multivariable Cox proportional hazards regression analyses were used to examine the relationship between β-arrestin1 and survival. The results demonstrated that a notably higher level of β-arrestin1 expression was found in lung ADC tissues. We also found that an elevated nuclear Β-arrestin1 correlates with higher intratumoral VEGF (P = 0.007). β-arrestin 1 over-expression indicated a poor 5-year overall survival (P = 0.016), and the Cox regression model confirmed that β-arrestin1 over-expression were independent prognostic factor for tumor progression (P = 0.027) and unfavorable overall survival (P = 0.015). We conclude that β-arrestin1 had a high expression in ADC and β-arrestin1 may be a promising biomarker to identify individuals with poor prognosis for patients with ADC. 相似文献
48.
Frequent co‐inactivation of the SWI/SNF subunits SMARCB1, SMARCA2 and PBRM1 in malignant rhabdoid tumours 下载免费PDF全文
49.
50.
Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation 下载免费PDF全文
Melatonin induces apoptosis in many different cancer cell lines, including colorectal cancer. However, the precise mechanisms involved remain largely unresolved. In this study, we provide evidence to reveal a new mechanism by which melatonin induces apoptosis of colorectal cancer LoVo cells. Melatonin at pharmacological concentrations significantly suppressed cell proliferation and induced apoptosis in a dose‐dependent manner. The observed apoptosis was accompanied by the melatonin‐induced dephosphorylation and nuclear import of histone deacetylase 4 (HDAC4). Pretreatment with a HDAC4‐specific siRNA effectively attenuated the melatonin‐induced apoptosis, indicating that nuclear localization of HDAC4 is required for melatonin‐induced apoptosis. Moreover, constitutively active Ca2+/calmodulin‐dependent protein kinase II alpha (CaMKIIα) abrogated the melatonin‐induced HDAC4 nuclear import and apoptosis of LoVo cells. Furthermore, melatonin decreased H3 acetylation on bcl‐2 promoter, leading to a reduction of bcl‐2 expression, whereas constitutively active CaMKIIα(T286D) or HDAC4‐specific siRNA abrogated the effect of melatonin. In conclusion, the present study provides evidence that melatonin‐induced apoptosis in colorectal cancer LoVo cells largely depends on the nuclear import of HDAC4 and subsequent H3 deacetylation via the inactivation of CaMKIIα. 相似文献